| Registro completo |
| Provedor de dados: |
BJM
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| País: |
Brazil
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| Título: |
Antimicrobial activity of allylic thiocyanates derived from the Morita-Baylis-Hillman reaction
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| Autores: |
Sá,Marcus Mandolesi
Ferreira,Misael
Lima,Emerson Silva
Santos,Ivanildes dos
Orlandi,Patrícia Puccinelli
Fernandes,Luciano
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| Data: |
2014-09-01
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| Ano: |
2014
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| Palavras-chave: |
Antimicrobial
Allylic thiocyanate
Morita-Baylis-Hillman reaction
MRSA
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| Resumo: |
Bacterial resistance to commonly used antibiotics has been recognized as a significant global health issue. In this study, we carried out the screening of a family of allylic thiocyanates for their action against a diversity of bacteria and fungi with a view to developing new antimicrobial agents. Allylic thiocyanates bearing halogenated aryl groups, which were readily obtained in two steps from the Morita-Baylis-Hillman adducts, showed moderate-to-high activity against selective pathogens, including a methicillin-resistant S. aureus (MRSA) strain. In particular cases, methyl (Z)-3-(2,4-dichlorophenyl)-2-(thiocyanomethyl)-2-propenoate exhibited antimicrobial activity comparable to the reference antibiotic Imipenem.
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| Tipo: |
Info:eu-repo/semantics/article
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| Idioma: |
Inglês
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| Identificador: |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1517-83822014000300007
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| Editor: |
Sociedade Brasileira de Microbiologia
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| Relação: |
10.1590/S1517-83822014000300007
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| Formato: |
text/html
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| Fonte: |
Brazilian Journal of Microbiology v.45 n.3 2014
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| Direitos: |
info:eu-repo/semantics/openAccess
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